Portia de Rossi
The actress had a run of hits from Ally McBeal to Scandal to Arrested Development, but she opted to quit acting just before turning 45, and asked Scandal creator Shonda Rhimes to write her character off the show.
She explained on wife Ellen DeGeneres’ talk show: “I kind of knew what acting would look like for me for the next 10, 20 years, so I decided to quit and start a business.”
She did make one exception, returning for the fifth season of Arrested Development (above) on Netflix in 2018. But since then, she’s chosen to focus on other aspects of life, earning this place on our esteemed list of actors who quit at the top.
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