There’s Something About Mary (1998)
What’s in Mary’s hair (above) will be enough to keep some people from liking this movie not matter what. There’s also plenty of bathroom and private parts humor (notably in the spectacular opening sequence) that the sensitive won’t be able to endure.
And if they get through that, the movie takes the radical approach that people with disabilities should be very much in the mix when it comes to the jokes — not as the butt of them, but taking and throwing shots along with everyone else.
All that said, There’s Something About Mary, like a lot of Farrelly Brothers movies— and ’90s movies — has a very big heart underneath all the gross-out jokes.